Expression of cyclins and cyclin dependent kinases in human benign and malignant melanocytic lesions
نویسندگان
چکیده
منابع مشابه
Expression of cyclins and cyclin dependent kinases in human benign and malignant melanocytic lesions.
AIMS The regulation of cell proliferation is a key event in normal development, pathophysiological responses to injury, and tumorigenesis. The orderly progression of cells through the cell cycle depends on a finely tuned balance between the concentrations of activated cyclins and cyclin dependent kinases. This study was undertaken to compare the expression of cell cycle regulators in benign and...
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Cyclins are the activating partners of a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). A number of diverse cyclins and CDKs are now known, many of which play important roles in the regulation of the eukaryotic cell cycle. However, it has recently become clear that the cyclin-CDK motif is used by the cell to control processes separate from the cell cycle, such ...
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Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins. Studies performed over more than a decade have supported the view that these holoenzymes are important, if not required, for these processes. However, recent ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 2001
ISSN: 0021-9746
DOI: 10.1136/jcp.54.3.229